Every home has a medication cabinet which has different medication. it is very important from time to time to clean it. Most medication will have an expiration date on it to tell you that it will not be good to use it after this date. (1) How often should you clean out your medicine cabinet? You should clean out your medicine cabinet at least once a year. Through away all expired medications, vitamins, and creams. It is important to through them away from children and pets.(2